こすぎ、武蔵小杉、新丸子近、糖尿病外来、内科、高血圧、クリニック サンマルコ クリニック
内分泌 ・ 糖尿病内科
Tel 044-433-3005


南 史朗


1.               若林一二, 南 史朗. 中枢神経とソマトスタチン. 最新医学 40: 926-931, 1985


2.               周東祐仁, 若林一二, 亀谷 純, 杉原 仁, 南 史朗. TSH不適合症候群の1家系. ホルモンと臨床 1: 136-140, 1992


3.               南 史朗. 成長ホルモンの中枢性自己分泌調節機構. 日本医科大学雑誌 65: 409-412, 1998


4.               南 史朗. 成長ホルモンのすべて—GH分泌調節機構「視床下部下垂体系に体するGH/IGF-1の作用と機序」. 内分泌・糖尿病科15 Suppl. 1, p. 84-90, 2002


5.               南 史朗, 中田朋子. タンパク・遺伝子からみた分子病新しく解明されたメカニズム「成長ホルモン受容体(GHR). 生体の科学56: 428-429, 2005


6.               南 史朗. GH/IGF-Iの分泌調節と経年変化.「成人成長ホルモン分泌不全症の臨床」千原和夫, 寺本明, 藤枝憲二編 メディカルレビュー社, p. 35-47, 2006


7.               南 史朗. 糖尿病緊急症(糖尿病性昏睡および低血糖発作).「内科エマージェンシー:病態生理の理解と診療の基本」救急医学20099月臨時増刊号3310, 黒川顕編, へるす出版, 1410-1414, 2009


8.               南 史朗. 下垂体ホルモンの分泌機構GH. 「下垂体腫瘍のすべて」, 寺本 明, 長村義之編, 医学書院, p16-26, 2009


9.               南 史朗, 八木 孝.  I. 下垂体疾患「ACTH単独欠損症」. 診断と治療 1007号別冊:1135-1141, 2012


10.            Fujita Y, Harada H, Takeuchi T, Sato H, Minami S. Enhancement of EEG spikes and hyperpolarizations of pyramidal cells in the kindled hippocampus of the rabbit. Japanese Journal of Physiology 33: 227-238, 1983


11.            Fujita Y, Sato H, Takeuchi T, Minami S. Median raphe- and contralateral hippocampus-elicited EEG spikes which correspond to hyperpolarizations of pyramidal cells in the kindled hippocampus of the rabbit. Brain Research 278: 313-317, 1983


12.            Minami S. Stimulation of the raphe nuclei produces EEG spikes in the hippocampus of the normal rabbit. Journal of Nippon Medical School 51: 557-567, 1984


13.            Minami S, Wakabayashi I, Tonegawa Y, Sugihara H, Akira S. Production of antisera to growth hormone-releasing factor: usefulness in radioimmunoassay and passive immunization.  Endocrinologica Japonica 32: 907-916, 1985


14.            Wakabayashi I, Hatano H, Minami S, Tonegawa Y, Akira S, Sugihara H, Ling N. Effects of neonatal administration of monosodium glutamate on plasma growth hormone (GH) response to GH-releasing factor in adult male and female rats. Brain Research 372: 361-365, 1986


15.            Mori T, Inoue S, Minami S, Egawa M, Wakabayashi I. Episodic growth hormone secretion following exogenous growth hormone-releasing factor in rats. Biomedical Research 7: 371-377, 1986


16.            Fujita Y, Harada H, Kitamura T, Minami S, Sato T. Dendritic activities of spinal motoneurones in pigs and rabbits enhanced through chronic stimulation of a dorsal root. Journal of Physiology (London) 383: 171-190, 1987


17.            Motoyama A, Wakabayashi I, Minami S, Sugihara H, Takahashi F, Akira S, Ling N. A radioimmunoassay for human pro-luteinizing hormone-releasing factor [pro-LRF(14-69)OH]. Endocrinologica Japonica 34: 133-137, 1987


18.            Akira S, Wakabayashi I, Sugihara H, Minami S, Takahashi F, Motoyama A. Effect of testosterone on growth hormone secretion in female rats during a continuous infusion of growth hormone releasing factor. Neuroendocrinology 47: 116-124, 1988


19.            Sugihara H, Wakabayashi I, Minami S, Takahashi F, Shibasaki T, Ling N. Effect of a-methyl-r-tyrosine and an antiserum to rat growth hormone (GH)-releasing factor (GRF) on plasma GH secretory profile during a continuous infusion of human GRF in rats. Brain Research 475: 128-133, 1988


20.            Sugihara H, Minami S, Wakabayashi I. Post-somatostatin rebound secretion of growth hormone is dependent on growth hormone-releasing factor in unrestrained female rats. Journal of Endocrinology 122: 583-591, 1989


21.            Minami S, Wakabayashi I, Sugihara H, Kamegai J, Hasegawa O, Kitamura T, Yamada J. Effect of intermittent infusions of somatostatin on growth hormone secretion in unrestrained male rats with hypothalamic deafferentation. Brain Research 509: 293-298, 1990


22.            Minami S, Frautschy SA, Plotsky PM, Sutton SW, Sarkar DK. Facilitatory role of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizing hormone-releasing hormone. Neuroendocrinology 52: 112-115, 1990


23.            Sarkar DK, Minami S. Effect of acute ethanol on beta-endorphin secretion from rat fetal hypothalamic neurons in primary cultures. Life Science 47: 31-36, 1990


24.            Okada K, Wakabayashi I, Sugihara H, Minami S, Kitamura T, Yamada J. Electrical stimulation of hypothalamic periventricular nucleus is followed by a large rebound secretion of growth hormone in unanesthetized rats. Neuroendocrinology 53: 306-312, 1991


25.            Kamegai J, Wakabayashi I, Sugihara H, Minami S, Kitamura T, Yamada J. Growth hormone secretion in stalk-sectioned rats. Acta Endocrinologica (Copenh) 124: 700-706, 1991


26.            Wakabayashi I, Inokuchi K, Hasegawa O, Sugihara H, Minami S.  Expression of growth hormone (GH)-releasing factor gene in GH-producing pituitary adenoma. Journal of Clinical Endocrinology and Metabolism 74: 357-361, 1992


27.            Hasegawa O, Sugihara H, Minami S, Wakabayashi I. Masculinization of growth hormone (GH) secretory pattern by dihydrotestosterone is associated with augmentation of hypothalamic somatostatin and GH-releasing hormone mRNA levels in ovariectomized adult rats.  Peptides 13: 475-481, 1992


28.            Shuto Y, Wakabayashi I, Amuro N, Minami S, Okazaki T. A point mutation in the 3,5,3'-triiodothyronine-binding domain of thyroid hormone receptor-α associated with a family with generalized resistance to thyroid hormone.  Journal of Clinical Endocrinology and Metabolism 75: 213-217, 1992


29.            Minami S, Kamegai J, Sugihara H, Hasegawa O, Wakabayashi I. Systemic administration of recombinant human growth hormone induces expression of the c-fos gene in the hypothalamic arcuate and periventricular nuclei in hypophysectomized rats. Endocrinology 131: 247-253, 1992


30.            Sarkar DK, Kim KH, Minami S. Transforming growth factor-β1 messenger RNA and protein expression in the pituitary gland: its action on prolactin secretion and lactotropic growth. Molecular Endocrinology 6: 1825-1833, 1992


31.            Minami S, Sarkar DK. Central administration of neuropeptide Y induces precocious puberty in female rats. Neuroendocrinology 56: 930-934, 1992


32.            Sugihara H, Minami S, Okada K, Kamegai J, Hasegawa O, Wakabayashi I. Somatostatin reduces transcription of the growth hormone gene in rats. Endocrinology 132: 1225-1229, 1993


33.            Kamegai J, Minami S, Sugihara H, Wakabayashi I. Barrel rotation evoked by intracerebroventricular injection of somatostatin and arginine-vasopressin is accompanied by the induction of c-fos gene expression in the granular cells of rat cerebellum. Molecular Brain Research 18: 115-120, 1993


34.            Okada K, Sugihara H, Minami S, Wakabayashi I. Effect of parenteral administration of selected nutrients and central injection of γ-globulin from antiserum to neuropeptide Y on growth hormone secretory pattern in food-deprived rats. Neuroendocrinology 57: 678-686, 1993


35.            Minami S, Kamegai J, Hasegawa O, Sugihara H, Okada K, Wakabayashi I. Expression of growth hormone receptor gene in rat hypothalamus. Journal of Neuroendocrinology 5: 691-696, 1993


36.            Hasegawa O, Minami S, Sugihara H, Wakabayashi I. Developmental expression of the growth hormone receptor gene in the rat hypothalamus. Developmental Brain Research 74: 287-290, 1993


37.            Mori T, Inoue S, Egawa M, Takamura Y, Minami S, Wakabayashi I. Impaired growth hormone secretion in VMH lesioned rats. International Journal of Obesity 17: 349-353, 1993


38.            Okada K, Suzuki N, Sugihara H, Minami S, Wakabayashi I. Restoration of growth hormone secretion in prolonged food-deprived rats depends on the level of nutritional intake and dietary protein. Neuroendocrinology 59: 380-386, 1994


39.            Sawada H, Sugihara H, Onose H, Minami S, Shibasaki T, Wakabayashi I. Effect of D-Ala-D-Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion in urethan-anesthetized rats. Regulatory Peptides 53: 195-201, 1994


40.            Kamegai J, Minami S, Sugihara H, Higuchi H, Wakabayashi I. Growth hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats. Endocrinology 135: 2765-2771, 1994


41.            Sarkar DK, Minami S. Diurnal variation in luteinizing hormone-releasing hormone and beta-endorphin release in pituitary portal plasma during the rat estrous cycle. Biology of Reproduction. 53: 38-45, 1995


42.            Suzuki N, Okada K, Sugihara H, Minami S, Wakabayashi I. Caloric intake stimulates growth hormone secretion in food-deprived rats with anterolateral deafferentation of the medial basal hypothalamus or administered antiserum to somatostatin. Journal of Neuroendocrinology 7: 483-490, 1995


43.            Minami S, Kamegai J, Sugihara H, Suzuki N, Higuchi H, Wakabayashi I.  Central glucoprivation evoked by administration of 2-deoxy-D-glucose induces expression of the c-fos gene in a subpopulation of neuropeptide Y neurons in the rat hypothalamus. Molecular Brain Research 33: 305-310, 1995


44.            Okada K, Suzuki N, Sugihara H, Minami S, Wakabayashi I. Effects of hyper- and hypoglycemia on blood growth hormone level in free-feeding rats with anterolateral deafferentation of the medial basal hypothalamus. Brain Research 699: 33-41, 1995


45.            Kamegai J, Minami S, Sugihara H, Hasegawa O, Higuchi H, Wakabayashi I. Growth hormone receptor gene is expressed in neuropeptide Y neurons in hypothalamic arcuate nucleus of rats. Endocrinology 137:2100-2112, 1996


46.            Minami S, Sugihara H, Sato J, Tatsukuchi A, Sugisaki Y, Sasano H, Wakabayashi I. ACTH independent Cushing's syndrome occurring in siblings [Case report] . Clinical Endocrinology  44: 483-488, 1996


47.            Kamegai J, Hasegawa O, Minami S, Sugihara H, Wakabayashi I. The growth hormone-releasing peptide KP-102 induces c-fos expression in the arcuate nucleus. Molecular Brain Research 39: 153-159, 1996


48.            Okada K, Ishii S, Minami S, Sugihara H, Shibasaki T, Wakabayashi I. Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats. Endocrinology 137: 5155-5158, 1996


49.            Suzuki N, Okada K, Minami S, Wakabayashi I. Inhibitory effect of neuropeptide Y on growth hormone secretion in rats is mediated by both Y1- and Y2-receptor subtypes and abolished after anterolateral deafferentation of the medial basal hypothalamus. Regulatory Peptides 65: 145-151, 1996


50.            Sugihara H, Emoto N, Shibasaki T, Minami S, Wakabayashi I. Increased pituitary growth hormone-releasing factor (GRF) receptor messenger ribonucleic acid expression in food-deprived rats. Brain Research 742: 355-358, 1996


51.            Minami S, Suzuki N, Sugihara H, Tamura H, Emoto N, Wakabayashi I. Microinjection of rat GH but not human IGF-I into a defined area of the hypothalamus inhibits endogenous GH secretion in rats. Journal of Endocrinology, 153: 283-290, 1997


52.            Tamura H, Sugihara H, Minami S, Emoto N, Shibasaki T, Shuto Y, Shimizu K, Gomi Y, Sasano H, Wakabayashi I. Cushing's syndrome due to bilateral adrenocortical adenomas with different pathological features [Case report]. Internal Medicine, 36: 804-809, 1997


53.            Minami S, Sarkar DK. Transforming growth factor b-1 inhibits prolactin secretion and lactotropic cell proliferation in the pituitary of estrogen-treated Fischer 344 rats. Neurochem Int 30: 499-506, 1998


54.            Minami S, Kamegai J, Sugihara H, Suzuki N, Wakabayashi I. Growth hormone inhibits its own secretion by acting on the hypothalamus through its receptors on neuropeptide Y neurons in the arcuate nucleus and somatostatin neurons in the periventricular nucleus. Endocrine Journal 45: S19-S26, 1998


55.            Emoto N, Onose H, Sugihara H, Minami S, Shimizu K, Wakabayashi I. Fibroblast growth factor-2 free form from extracellular matrix is increased in papillary thyroid carcinomas and graves' thyroids.  Thyroid 8: 491-497, 1998


56.            Emoto N, Onose H, Yamada H, Minami S, Tushima T, Wakabayashi I. Growth factors increase pericellular proteoglycans independently of their mitogenic effects on A10 rat vascular smooth muscle cells. Int J Biochem Cell Biol 30: 47-54, 1998


57.            Minami S, Nakata T, Tokita R, Onodera H, Imaki J. Cellular localization of prolactin-releasing peptide messenger RNA in the rat brain. Neuroscience Letters 266: 73-75, 1999


58.            Tokita R, Nakata T, Katsumata H, Konishi S, Onodera H, Imaki J, Minami S. Prolactin secretion in response to prolactin-releasing peptide (PrRP) and the expression of the PrRP gene in the medulla oblongata are estrogen dependent in rats. Neuroscience Letters 276: 103-106, 1999


59.            Sugihara H, Emoto N, Tamura H, Kamegai J, Shibasaki T, Minami S, Wakabayashi I. Effect of insulin-like growth factor-I on growth hormone-releasing factor receptor expression in primary rat anterior pituitary cell culture. Neurosci Lett 276: 87-90, 1999


60.            Yokota T, Nakata T, Minami S, Inazawa J, Emi M. Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma. J Hum Genet 45: 5-11, 2000


61.            Tamura H, Sugihara H, Kamegai J, Minami S, Wakabayashi I. Masculinizing effect of dihydrotestosterone on growth hormone secretion is inhibited in ovariectomized rats with anterolateral deafferentation of the medial basal hypothalamus or in intact female rats. J Neuroendocrinol 12: 369-375, 2000


62.            Chikada N, Imaki T, Harada S, Nakajima K, Yoshimoto T, Naruse M, Demura H, Minami S, Takano K. Distribution of c-fos mRNA in the brain following intracerebroventricular injection of nitric oxide (NO)-releasing compound: possible role of NO in central cardiovascular regulation. J Neuroendocrinol 12: 1112-1123, 2000


63.            Imaki T, Katsumata H, Miyata M, Naruse M, Imaki J, Minami S. Expression of corticotropin-releasing factor (CRF), urocortin, and CRF type 1 receptors in hypothalamic-hypophyseal systems under osmotic stimulation. J Neuroendocrinol 13: 328-338, 2001


64.            Imaki T, Katsumata H, Miyata M, Naruse M, Imaki J, Minami S. Expression of corticotropin-releasing hormone type 1 receptor in paraventricular nucleus after acute stress. Neuroendocrinology 73: 293-301, 2001


65.            Ogata K, An E, Shioi Y, Nakamura K, Luo S, Yokose N, Minami S, Dan K. Association between natural killer cell activity and infection in immunologically normal elderly people. Clinical and Experimental Immunology 124: 392-397, 2001


66.            Nakata T, Yokota T, Emi M, Minami S. Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. Genes, Chromosomes & Cancer 35: 30-37, 2002


67.            Tokita R, Kasagi Y, Nakata T, Sakae K, Imaki T, Minami S. Microinjection of dihydrotestosterone into the medial preoptic area produces male-like pattern of growth hormone secretion in ovariectomized female rats. Neuroendocrinology 75: 384-391, 2002


68.            Konishi S, Kasagi Y, Katsumata H, Minami S, Imaki T. Regulation of corticotropin-releasinga factor (CRF) type-1 receptor gene expression by CRF in the hypothalamus. Endocrine Journal 50: 21-36, 2003


69.            Imaki T, Katsumata H, Konishi S, Kasagi Y, Minami S.  Corticotropin-releasing factor type-1 receptor mRNA is not induced in mouse hypothalamus by either stress or osmotic stimulation. J Neuroenodocrinol 15: 916-924, 2003


70.            Kasagi Y, Tokita R, Nakata T, Imaki T, Minami S. Human growth hormone induces SOCS3 and CIS mRNA increase in the hypothalamic neurons of hypophysectomized rats. Endocrine J 51, 145-154, 2004


71.            Toyoshima Y, Hakuno F, Kato H, Minami S, Takahashi SI. Hepatic insulin signals are enhanced in rats fed on low-protein diets, a model of IGF resistance. Growth Horm IGF Res 18 S23, 2008


72.            Suzuki N, Tsumoto K, Hajicek N, Daigo K, Tokiga R, Minami S, Kodama T, Hamakubo T, Kozasa T. Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface. J Biol Chem 284: 5000-9, 2009


73.            Osaka M, Tokita R, Minami S. Volley-like male GH secretion indicates existence of an intrinsic 1-h oscillator in the hypothalamus. Applied Mathematical and Computational Sciences 1, 225-242, 2010


74.            Toyoshima Y, Tokita R, Ohne Y, Hakuno F, Noguchi T, Minami S, Kato H, Takahashi S. Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver. J Molecular Endocrinology 45: 329-340, 2010


75.            Cha P-C, Mushiroda T, Takahashi A, Kubo M, Minami S, Kamatani N, Nakamura Y. Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. Human Molecular Genetics 19: 4735-4744, 2010


76.            Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S. Phosphatidylinositol 3-kinase-binding protein, PITKAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells. Mol Endocrinol 26: 1043-55, Epub, 2012


77.            Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S. Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation. J Biol Chem 287: 29713-21, 2012


78.            Okamoto Y, Ishii So, Croce K, Katsumata H, Fukushima M, Kihara S, Libby P, Minami S. Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques. Atherosclerosis 226: 373-377, 2013


79.            Ishii S, Okamoto Y, Katsumata H, Minami S. Sunitinib, a small-molecule receptor tyrosine kinase inhibitor, suppresses neointimal hyperplasia in balloon-injured rat carotid artery. J Cardiovascular Pharmacology and Therapeutics 18: 359-266, 2013


80.            Kaneko M, Hakuno F, Kamei H, Yamanaka D, Chida K, Minami S, Coe IR, Takahashi S. Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters. Biochem Biophys Res Com 443: 505-510, 2014


81.            Ishikawa M, Tachibana T, Hashimoto H, Toyomura J, Ito T, Tsuboi K, Shibuya K, Hirose T, Minami S, Yoshino G. Functional analysis of three novel cell lines derived from human papillary thyroid carcinomas with three different clinical courses. Human Cell 27: 111-120, 2014


82.            Toyoshima Y, Tokita R, Taguchi Y, Akiyama-Akanishi N, Takenaka A, Kato H, Chida K, Hakuno F, Minami S, Takahashi S. Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats. Endocrine J 61: 499-512, 2014


83.            Fukushima M, Okamoto Y, Katsumata H, Ishikawa M, Ishii S, Okamoto M, Minami S. Growth hormone ameliorate adipose dysfunction during oxidative stress and inflammation and improves glucose tolerance in obese mice. Hormone and Metabolic Research 46: 656-662, 2014


84.            Orikasa C, Nagaoka K, Katsumata H, Minami S, Kondo Y, Sakuma Y.  Social isolation prompts maternal behavior in sexually naïve male ddN mice. Physiology & Behavior 151: 9-15, 2015


85.            Yamanaka D, Akama T, Chida K, Minami S, Ito K, Hakuno F, Takahashi S. Phosphatidylinositol 3-kinase-associated protein (PI3KAP)/XB130 crosslinks actin filaments through its actin binding and multimerization properties in vitro and enhances endocytosis in HEK293 cells. Front Endocrinol (Lausanne) 7: Article 89, 2016


86.            Zhou H, Mori S, Ishizaki T, Takahashi A, Matsuda K, Koretsune Y, Minami S, Higashiyama M, Imai S, Yoshimori K, Doita M, Yamada A, Nagayama S, Kaneko K, Asai S, Shiono M, Kubo M, Ito H. Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis. Bone Reports 5: 158-172, 2016


87.            Orikasa C, Kondo Y, Katsumata H, Terada M, Akimoto T, Sakuma Y, Minami S. Vomeronasal signal deficiency enhances parental behavior in socially isolated male mice.  Physiology & behavior 168: 98-102, 2017


88.            Taguchi Y, Toyoshima Y, Tokita R, Kato H, Takahashi S, Minami S. Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling. Biochem Biophys Res Com 490: 800-805, 2017


89.            Minami S, et al. Biobank Japan project: Epidemiological study.  Journal of Epidemiology 27-3S: S1-S106, 2017


90.            Mushiroda T, Takahashi Y, Omura T, Yamamoto Y, Kamei T, Hoshida T, Takeuchi K, Otsuka K, Okazaki M, Watanabe M, Kanemoto K, Odshima T, Watanabe A, Minami S, Saito K, Tanii H, Shimo Y, Hara M, Saito S, Kinoshita T, Kato M, Yamada N, Akamatsu N, Fukuchi T, Ishida S, Yasumoto S, Takahashi A, Ozeki T, Furuta T, Saito Y, Izumida N, KanoY, Shiohara T, Kubo M. Association of HLA-A*31:01 screening with the incidence of carbamazepine-induced cutaneous adverse reactions in a Japanese population. JAMA Nuerology 75(7): 842-849, 2018


91.            Yano H, Sakai M, Yagi T, Naganuma T, Matsukawa T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, Kaburagi Y, Asahara S, Kido Y, Minami S, Kasuga M, Matsumoto M. PHD3 regulates glucose metabolism by suppressing stress-induced signaling and optimizing gluconeogenesis and insulin signaling in hepatocytes. Scientific Reports 8: 14290, 2018


92.            Yagi T, Toyoshima Y, Tokita R, Taguchi Y, Okamoto Y, Takahashi S, Kato H, Mianmi S. Low-protein diet enhances adiponectin secretion in rats. Bioscience, Biotechnology, and Biochemistry 83: 1774-1781, 2019


93.            Nakata T, Hirano Y, Katsumata H, Tokita R, Yagi T, Toyoshima Y, Minami S. Growth hormone activates X-box binding protein 1 in a sexually dimorphic manner through the extracellular signal-regulated protein kinase and CCAAT/enhancer-binding protein β pathway in rat liver. Endocr J 67: 185-200, 2020


94.            Toyoshima Y, Yoshizawa F, Tokita R, Taguchi Y, Takahashi S, Kato H, Minami S. A translation repressor, 4E-BP1, regulates the triglyceride level in rat liver during protein deprivation. Am J Physiol Endocrinol Metab. 318: E636-E645, 2020


95.            Ishikawa M, Brooks AJ, Fernandez-Rojo MA, Medina J, Chhabra Y, Minami S, Tunny KA, Parton RG, Vivian JP, Rossjohn J, Chikani V, Ramm GA, Ho KKY, Waters MJ. Growth hormone stops excessive inflammation after partial hepatectomy allowing liver regeneration and survival via induction of H2-Bl/HLA-G. Hepatology: 2020 Apr 27. doi: 10.1002/hep.31297, https://doi.org/10.1002/hep.31297


96.            Nakata T, Toyoshima Y, Yagi T, Katsumata H, Tokita R, Minami S. Growth hormone increases regulator of calcineurin 1-4 (Rcan 1-4) mRNA through c-JUN in rat liver. PLOS One: Published: June 26, 2020: https://doi.org/10.1371/journal.pone.0235270


97.            Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low S-K, Okada Y, Terao C, Amariuta T, Gazal F, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Yasushi, Sakata Yasuhiko, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M & Kamatani Y. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nature Genetics 52: 669–679, 2020: Letter, Published: 08 June 2020


98.            Ishikawa M, Toyomura J, Yagi T, Kuboki K, Morita T, Sugihara H, Hirose T, Minami S, Yoshino G. Role of growth hormone signaling pathways in the development of atherosclerosis. Growth Hormone & IGF Research 53-54: 101334, 2020


99.            Toyoshima Y, Nakamura K, Tokita R, Teramoto N, Sugihara H, Kato H, Yamanouchi K, and Minami S. Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. J Biol Chem 295(33):11914-11927, 2020


100.         Orikasa C, Kato Y, Katsumata H, Inutsuka A, Yamanaka A, Onaka T, Minami S. Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior. Scientific Reports (in press)


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Librae リブレ

500円玉より一回り大きいセンサーを皮膚に貼り付けると、2週間の間、自動的に血糖値をモニターしてくれます。 センサーにリーダーをかざすだけで血糖値がわかります。 血糖コントロールの劇的な改善をもたらします。
Librae リブレ

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TEL: 044-433-3005

Dexcom G4 デキスコムG4

皮膚にセンサーを取り付けると、1週間の間、自動的に血糖値をモニタ―してくれます。 小型のモニターでいつでも血糖値を見ることができます。 誤差が少なく、低血糖・高血糖の警報音が鳴ります。
Dexcom G4 デキスコムG4 Dexcom G4 デキスコムG4

サンマルコ クリニック
TEL: 044-433-3005


CSII: Continuous Subcutaneous Insulin Infusion ミニメド640G
インスリンを針を付けた注射器で注射するのではなく、皮膚に留置した柔らかいチューブを通して持続的に注入する方法です。 食事のたびに注射をする必要がなく、適切な量のインスリンを注入できます。 厳密な血糖管理を必要とする人向けです

サンマルコ クリニック
TEL: 044-433-3005

SAP (Sensor Augmented Pump) 療法

インスリンポンプ療法を行いつつ、持続血糖モニタリング(CGM :Continuous Glucose Monitering) を行います。 CGMとインスリンポンプがブルートゥースで連動し、血糖値がインスリンポンプのモニター画面に表示されます。 妊婦など、より厳密な血糖コントロールを求める人向けです。
SAP (Sensor Augmented Pump) 療法

サンマルコ クリニック
TEL: 044-433-3005

Medisafe With メディセーフウィズ

チューブのないウエアラブルのインスリン持続注入ポンプです。 チューブの付いたポンプを腰に下げる必要がありません。 無線のリモコン装置で、インスリン基礎レートの設定やボラス注入ができます。日本の会社テルモが開発した製品です。

サンマルコ クリニック
TEL: 044-433-3005


(CPAP: Continuous Positive Airway Pressure) CPAP療法は睡眠時無呼吸に対して有効な治療法です。 睡眠中に、鼻から気道に常に陽圧をかけることで、睡眠中の気道の閉塞を防ぎます。いびきをかかなくなり、無呼吸も無くなります。 口腔衛生にもなり、歯周病予防になります。

サンマルコ クリニック
TEL: 044-433-3005